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Download Case Study: Disease Registries Development with OMOP-CDM Repository

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Disease Registries with OMOP/CDM Repository




Our client is an innovative company that has developed a platform for rare disease registries and is building registries and supporting related research in multiple countries. Each registry aggregates data from multiple sources including EHR and other systems.

The internal operational patient data representation is based on the OHDSI OMOP/CDM open-source data model. The company has also been developing an extensive technical and content management infrastructure as well as the necessary metadata model and CDM extension in support of its business objectives.

Our client has several teams spread over three continents working internally and with customers.

Engagement Scope and Details

Our client has engaged First Line based on our extensive experience in Healthcare and due to our unique OMOP/CDM expertise.

In support of the client's needs, we have assembled a multi-functional team that works in close contact with the leadership and the management using agile processes.

As part of this engagement, we are working with a wide range of data-related and infrastructure tasks, including:

  • The rapid evolution of a multi-tenant cloud-based interactive platform for data collection that supports workflows and logic for clinicians, patients, and researchers
  • Building an integration pipeline with Healthcare institutions that utilizes intelligent patient matching, data profiling, and data quality functions
  • Transformation and mapping of patient data from different EHR systems and legacy data sources to OMOP/CDM
  • Data modeling for numerous observational entities of high complexity in support of specific diseases and workflows
  • Development of clinical content management tools and infrastructure for collaboration of researchers and clinicians.

Technical Implementation Highlights

  • Cloud-based multitenant solution hosted in Microsoft Azure
  • Technology stack: Single page architecture, Angular JS, Java Bootstrap, microservices, Microsoft SQL Server Database, Forgerock
  • Integration pipeline is based on Intersystems HealthConnect infrastructure
  • Intelligent patient matching using open source machine learning software and algorithms
  • Persistent storage in OMOP/CDM and extensions; shadow storage for UI is in JSON
  • Data conversion from external sources in CCDA, FHIR, HL7, proprietary interfaces, and data formats to OMOP/CDM and JSON


OMOP CDM is a Common Data Model open-source standard for representation of observational data used for conducting clinical research based on the Real World Evidence (RWE). It is supported and maintained by the OHDSI international community.

The CDM allows users to generate evidence from a wide variety of sources. It has been widely adopted by life sciences companies, healthcare organizations, and research communities. It supports collaborative research across data sources around the globe.

OMOP/CDM is also highly extensible and can accommodate extensions and custom entities outside of the standard set.

First Line Expertise in OMOP/CDM

As a healthcare software development company, First Line, has a team of analysts, Medical Informaticians, and engineers with deep expertise in OMOP/CDM who have been mapping and extracting observational data from a variety of data sources, modeling complex observational entities, and developing tools and applications around OMOP/CDM for research and analytics.

Download the case study by clicking the PDF icon above or refer to clients' references and other related projects below.

Download Case Study: Disease Registries Development with OMOP-CDM Repository

Download Case Study

Client References

I want to express my gratitude for all of your team’s hard work, support and extra help. We are very grateful for all that you have done for us.

Senior Project Manager, a U.S. specialty digital design and web development agency

Your quality of work is exceptional, and your flexible approach has allowed us to build and deploy a large amount of complex functionality in a very short space of time. Kudos to everyone for their professionalism and for delivering results that exceeded our expectations.

CEO, leading social media analytics provider

We have never had a better release that we can think of. And that is all because of your hard and dedicated work. So here is a big THANK YOU to everyone from all of us!

Editor, leading Scandinavian newspaper

For a software vendor like ourselves, picking the right development partner is crucial. First Line’s technical expertise and solid project management, coupled with their proficiency in Agile methodologies, have made them an integral part of our product development group.

VP Product Development, leading enterprise software vendor

Our First Line Team has been doing a great job. All of the guys check in great code, and they have a forward thinking mindset, not a feature-to-feature approach. They are also very open in terms of sharing knowledge, which is critical to running productive distributed teams.

Application Development Director, global marketing company

We've all learned a lot from you, and it is great working with you.

Application Development Director, global marketing company

The First Line team has an excellent process and we can learn from your team and improve.

Product Owner, Strategic Software Consultancy

I would like to thank the First Line development team for their dedication and high level of quality in their work. Despite being thousands of miles apart, we have been able to work quickly, effectively, and intelligently. Your team has been a major part of why we have been successful thus far.

VP Engineering, e-learning startup

First Line is a great technology partner capable of delivering complex, ‘industrial grade’ projects. They have demonstrated strong technical competence and solid understanding of the media and publishing domain. We have also been very impressed by the management team's attention to our needs and commitment to our success.

CEO, leading European digital media company

Your effort is the #1 reason that this project is going so well. I've worked with a lot of teams over the years and there are very few teams that I trust and respect. When you are given a task or feature, I never have to worry whether or not it will be accomplished on time and I never worry about the quality - you always deliver.

Architect, Strategic Software Consultancy

The team we put together in the last half of this year is one of the most productive, skilled and enjoyable I’ve ever worked on. It’s great to see the product brought to life, and I’m proud to work with all you folks.

Senior Architect, Fortune 100 company

The First Line Software team is professional, results driven, and proactive. I know that when we provide requirements for new functionality, they will not only deliver on the scope of what has been asked but will look beyond and give insight into how we can make our product even better. It has been a privilege to work with First Line Software, and I look forward to continuing our partnership in future.

VP, global marketing company
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